Profile

Scientific CV:
1988-1993 undergraduate study, Prague Institute of Chemical Technology , M. S. degree - specialization organic and medicinal chemistry (supervisor Prof. J. Kuthan)
1993-1996 PhD study, Institute of Organic Chemistry and Biochemistry , Academy of Sciences of the Czech Republic (supervisor Dr. A. Holý)
1997 one-year post-doctoral stay at the Department of Chemistry, Université Catholique de Louvain , Louvain-la-Neuve, Belgium (supervisor Prof. L. Ghosez)
1998-2002 staff scientist, Institute of Organic Chemistry and Biochemistry , Academy of Sciences of the Czech Republic .
since 2002 group leader at IOCB
2006 DSc. degree at the Academy of Sciences of the Czech Republic
2006 habilitation at the Institute of Chemical Technology Prague - Associate professor
2011-2014 Associate professor (part time) at the Charles University, Dept. of Organic and Nuclear Chemistry
since 2014 Full professor (part time) at the Charles University, Dept. of Organic Chemistry

Professional membership:
Czech Chemical Society , American Chemical Society , International Society for Nucleosides, Nucleotides and Nucleic Acids

Membership in editorial boards:
1998-2011 journal Collect. Czech. Chem. Commun. - Editor-in-Chief
since 2011 journal ChemBioChem - member of Editorial Advisory Board
since 2011 journal ChemPlusChem - co-chairman and member of the Editorial Advisory Board
since 2013 F1000 faculty member for Chemical biology

Awards:
1999 Alfred Bader Prize for excellent results of young scientist in organic and bioorganic chemistry.
2004 Otto Wichterle Premium for Younger Scientists
2004 Prize of the Academy of Sciences for Younger Scientists
2015 Praemium Academiae from the Czech Academy of Sciences
2015 Fellow of ChemPubSoc Europe
2017 Elected member of the Learned Society of the Czech Republic
2019 Rudolf Lukes Prize from the Czech Chemical Society

Main research interests:

    chemistry of nucleobases, nucleosides, nucleotides and nucleic acids
    application of transition metal catalyzed reactions in organic synthesis
    medicinal chemistry
    chemical biology

Latest publications

Glyco-DNA: Enzymatic synthesis of base-modified and hypermodified DNA displaying up to four different monosaccharide units in the major groove
Chemistry - A European Journal 2024: Early View
Synthesis and Biological Profiling of Quinolino-Fused 7-Deazapurine Nucleosides
ACS Omega 9 (18): 20557–20570 (2024)
Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases
Nature Communications 15: 3054 (2024)
Superanionic DNA: enzymatic synthesis of hypermodified DNA bearing four different anionic substituents at all four nucleobases
Nucleic Acids Research 51 (21): 11428–11438 (2023)