Profile

Scientific CV:
1988-1993 undergraduate study, Prague Institute of Chemical Technology , M. S. degree - specialization organic and medicinal chemistry (supervisor Prof. J. Kuthan)
1993-1996 PhD study, Institute of Organic Chemistry and Biochemistry , Academy of Sciences of the Czech Republic (supervisor Dr. A. Holý)
1997 one-year post-doctoral stay at the Department of Chemistry, Université Catholique de Louvain , Louvain-la-Neuve, Belgium (supervisor Prof. L. Ghosez)
1998-2002 staff scientist, Institute of Organic Chemistry and Biochemistry , Academy of Sciences of the Czech Republic .
since 2002 group leader at IOCB
2006 DSc. degree at the Academy of Sciences of the Czech Republic
2006 habilitation at the Institute of Chemical Technology Prague - Associate professor
2011-2014 Associate professor (part time) at the Charles University, Dept. of Organic and Nuclear Chemistry
since 2014 Full professor (part time) at the Charles University, Dept. of Organic Chemistry

Professional membership:
Czech Chemical Society , American Chemical Society , International Society for Nucleosides, Nucleotides and Nucleic Acids

Membership in editorial boards:
1998-2011 journal Collect. Czech. Chem. Commun. - Editor-in-Chief
since 2011 journal ChemBioChem - member of Editorial Advisory Board
since 2011 journal ChemPlusChem - co-chairman and member of the Editorial Advisory Board
since 2013 F1000 faculty member for Chemical biology

Awards:
1999 Alfred Bader Prize for excellent results of young scientist in organic and bioorganic chemistry.
2004 Otto Wichterle Premium for Younger Scientists
2004 Prize of the Academy of Sciences for Younger Scientists
2015 Praemium Academiae from the Czech Academy of Sciences
2015 Fellow of ChemPubSoc Europe
2017 Elected member of the Learned Society of the Czech Republic
2019 Rudolf Lukes Prize from the Czech Chemical Society

Main research interests:

    chemistry of nucleobases, nucleosides, nucleotides and nucleic acids
    application of transition metal catalyzed reactions in organic synthesis
    medicinal chemistry
    chemical biology

Latest publications

Homologues of epigenetic pyrimidines: 5-alkyl-, 5-hydroxyalkyl and 5-acyluracil and -cytosine nucleotides: synthesis, enzymatic incorporation into DNA and effect on transcription with bacterial RNA polymerase
RSC Chemical Biology 3 (8): 1069-1075 (2022)
Epigenetic Pyrimidine Nucleotides in Competition with Natural dNTPs as Substrates for Diverse DNA Polymerases
ACS Chemical Biology 2022: Early View
Glucosylated 5-Hydroxymethylpyrimidines as Epigenetic DNA Bases Regulating Transcription and Restriction Cleavage
Chemistry - A European Journal 28 (31): e202200911 (2022)
Glyoxal-Linked Nucleotides and DNA for Bioconjugations and Crosslinking with Arginine-Containing Peptides and Proteins
Chemistry - A European Journal 28 (14): e202104208 (2022)