Invited Lecture – Nenad Ban

20 June 2022
IOCB Prague
Invited Lecture – Nenad Ban

Prof. Nenad Ban (Institute of Molecular Biology and Biophysics, ETH Zurich, Switzerland)


Structural Basis of Protein Synthesis in Eukaryotes: from Basic Principles to Translation in Coronavirus Infected Cells

Date and time

20 June 2022, 10 a.m.


IOCB Prague, Lecture Hall


We are investigating bacterial and eukaryotic ribosomes and their functional complexes to obtain insights into the process of protein synthesis. Building on our studies aimed at revealing the structures of eukaryotic cytosolic and mitochondrial ribosomes, we are now investigating eukaryotic translation initiation, targeting of proteins to membranes, regulation of protein synthesis, and how viruses reprogram host translation. Previously, we studied how Hepatitis C virus genomic RNA can bind mammalian ribosomes to achieve translation of viral mRNAs in the absence of some canonical cellular translation initiation factors (Quade et al. 2015). With our recent research activities we contributed to the understanding of how SARS-CoV-2, the virus that is responsible for the COVID-19 pandemic, shuts off host translation to prevent cellular defence mechanisms against the virus (Schubert et al. 2020). Furthermore, using a combination of cryo-electron microsocpy and biochemical assays we also investigated the mechanism of programmed ribosomal frameshifting, one of the key events during translation of the SARS-CoV-2 RNA genome that leads to synthesis of the viral RNA-dependent RNA polymerase and downstream viral proteins (Bhat et al. 2020). 


  • Quade N, Boehringer D, Leibundgut M, van den Heuvel J, Ban N. Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution. Nat. Commun. 2015, 6, 7646.
  • Schubert K, Karousis ED, Jomaa A, Scaiola A, Echeverria B, Gurzeler LA, Leibundgut M, Thiel V, Mühlemann O, Ban N. (2020) SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation. Nat. Struct. Mol. Biol. 2020, 27, 959-966.
  • Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, Dreos R, O'Connor KM, McMillan A, Bode JW, Thiel V, Gatfield D, Atkins JF, Ban N. (2021) Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science 2021, 372 (6548), 1306-1313. 


From the left: Dr. Irena Stará, IOCB Invited Lectures Series organizer; Prof. Jan Konvalinka, IOCB Prague director; Prof. Nenad Ban, ETH Zurich; Dr. Pavlína Maloy Řezáčová, IOCB Prague vice-director for research. Photo: Michal Hoskovec / IOCB Prague Photo: Michal Hoskovec / IOCB Prague Photo: Michal Hoskovec / IOCB Prague Photo: Michal Hoskovec / IOCB Prague Photo: Michal Hoskovec / IOCB Prague Photo: Michal Hoskovec / IOCB Prague
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