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Huw M. L. Davies

18 September 2018
IOCB Prague
Speaker
Prof. Huw M. L. Davies (Department of Chemistry, Emory University, Atlanta, Georgia, USA)
Topic
Catalyst-Controlled Site-Selective and Stereoselective C–H Functionalization
Date and time
18 September 2018, 10 a.m.
Place
IOCB Prague, Lecture Hall (Building A, 2nd floor, A2.01)

Abstract

The development of practical methods for site selective C-H functionalization is of intense current interest. This presentation will describe a collaborative approach towards achieving new C-H functionalization strategies and our recent advances in the C-H insertion chemistry of donor/acceptor-substituted carbenoids. A series of chiral dirhodium catalysts have been developed for this chemistry and they are capable of controlling which C-H bond is functionalized.1,2 The application of these new synthetic strategies to the synthesis of natural products and pharmaceutical targets will be described.

References

  1. Liao, K.; Negretti, S.; Musaev, D. G.; Bacsa, J.; Davies, H. M. L. Nature, 2016, 533, 230.
  2. Liao, K.; Pickel, T. C.; Boyarskikh, V.; Bacsa, J.; Musaev, D.G.; Davies, H .M. L. Nature, 2017, 551, 609.
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