Zvaná přednáška – Huw M. L. Davies

18. září 2018
Zvaná přednáška – Huw M. L. Davies

Prof. Huw M. L. Davies (Department of Chemistry, Emory University, Atlanta, Georgia, USA)


Catalyst-Controlled Site-Selective and Stereoselective C–H Functionalization

Datum a čas

18. září 2018, 10:00


Přednáškový sál ÚOCHB (budova A, 2. NP, A2.01) 


The development of practical methods for site selective C-H functionalization is of intense current interest. This presentation will describe a collaborative approach towards achieving new C-H functionalization strategies and our recent advances in the C-H insertion chemistry of donor/acceptor-substituted carbenoids. A series of chiral dirhodium catalysts have been developed for this chemistry and they are capable of controlling which C-H bond is functionalized.1,2 The application of these new synthetic strategies to the synthesis of natural products and pharmaceutical targets will be described.


  1. Liao, K.; Negretti, S.; Musaev, D. G.; Bacsa, J.; Davies, H. M. L. Nature, 2016, 533, 230.
  2. Liao, K.; Pickel, T. C.; Boyarskikh, V.; Bacsa, J.; Musaev, D.G.; Davies, H .M. L. Nature, 2017, 551, 609.

Foto: Michal Hoskovec / ÚOCHB Foto: Michal Hoskovec / ÚOCHB
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