List of PhD projects in 2023

CHEM cluster

Synthesis and application of N-fluoroalkylated compounds (Petr Beier Group)
Enzymatic synthesis of base-modified RNA (Michal Hocek Group)
Modified nucleotides for selection of functional nucleic acids (Michal Hocek Group)
New modified nucleosides and nucleotides as potential receptor modulators (Michal Hocek Group)
Design and synthesis of inhibitors of purine salvage pathway enzymes (Zlatko Janeba Group)
Design and synthesis of novel azo-based photoswitches (Zlatko Janeba Group)
Molecular propulsion units (Jiří Kaleta Group)
Multiphotochromic molecular machines (Jiří Kaleta Group)
Synthesis of low-molecular compounds for specific targeting of important therapeutic targets (Jan Konvalinka Group)
Synthesis of biologically active neurosteroids (Eva Kudová Group)
Inhibitors of viral methyltransferases (Radim Nencka Group)
Catalytic stereoselective synthesis of elusive atropisomers for drug discovery (Paulo Paioti Group)
Photochemistry and spectroscopy of organic radical ions (Tomáš Slanina Group)
Helically chiral ligands for asymmetric transition metal catalysis (Ivo Starý Group)
Synthesis and chiroptical properties of helicene-derived luminophores (Ivo Starý Group)
Development of new chemical tools to study cell-cell interactions (Milan Vrábel Group)

Development of deoxyribozyme sensors (Edward Curtis Group)
Deoxyribozyme discovery using single-step selections (Edward Curtis Group)
In vitro evolution and engineering of XNA polymerases (Michal Hocek Group)
Viral proteases of important human pathogens (Jan Konvalinka Group)
Regulation of proteolysis in biomedicine (Michael Mareš Group)
Protein complexes in nucleosomal context (Pavlína Řezáčová Group)
Structural studies of medicinally relevant proteins and their complexes (Pavlína Řezáčová Group)
Inhibitors of intramembrane proteases of the rhomboid family (Kvido Stříšovský Group)
Novel mechanisms of regulation of the ADAM17 metalloprotease for anti-inflammatory and anti-obesity strategies (Kvido Stříšovský Group)
Characterization of Hepatitis B virus – host cell interaction networks and their role in viral pathogenesis (Jan Weber Group)

Development of a methodology for protein analysis by native CE-MS (Václav Kašička Group)