IOCB Most Significant Publications 2021

The most significant publications in CHEM, BIO & PHYS clusters are selected annually by an external international panel of reviewers and the IOCB director.

The awarded publications are listed in their respective clusters alphabetically by title.

• Leone, D.-L.; Hubálek, M.; Pohl, R.; Sýkorová, V.; Hocek, M. 1,3-Diketone-Modified Nucleotides and DNA for Cross-Linking with Arginine-Containing Peptides and Proteins. Angew. Chem. Int. Ed. 2021, 60, 17383-17387. http://dx.doi.org/10.1002/anie.202105126
• Kodr, D.; Yenice, C. P.; Simonova, A.; Saftić, D. P.; Pohl, R.; Sýkorová, V.; Ortiz, M.; Havran, L.; Fojta, M.; Lesnikowski, Z. J.; O’Sullivan, C. K.; Hocek, M. Carborane- or Metallacarborane-Linked Nucleotides for Redox Labeling. Orthogonal Multipotential Coding of all Four DNA Bases for Electrochemical Analysis and Sequencing. J. Am. Chem. Soc. 2021, 143, 7124-7134. http://dx.doi.org/10.1021/jacs.1c02222
• Dzijak, R.; Galeta, J.; Vázquez, A.; Kozák, J.; Matoušová, M.; Fulka, H.; Dračínský, M.; Vrabel, M. Structurally Redesigned Bioorthogonal Reagents for Mitochondria-Specific Prodrug Activation. JACS Au 2021, 1, 23-30. http://dx.doi.org/10.1021/jacsau.0c00053
• Svehlova, K.; Lukšan, O.; Jakubec, M.; Curtis, E. A. Supernova: A Deoxyribozyme that Catalyzes a Chemiluminescent Reaction. Angew. Chem. Int. Ed. 2022, 61, e202109347. http://dx.doi.org/10.1002/anie.202109347
• Pimková Polidarová, M.; Břehová, P.; Kaiser, M. M.; Smola, M.; Dračínský, M.; Smith, J.; Marek, A.; Dejmek, M.; Šála, M.; Gutten, O.; Rulíšek, L.; Novotná, B.; Brázdová, A.; Janeba, Z.; Nencka, R.; Boura, E.; Páv, O.; Birkuš, G. Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP). J. Med. Chem. 2021, 64, 7596-7616. http://dx.doi.org/10.1021/acs.jmedchem.1c00301

• Cermakova, K. ; Demeulemeester, J.; Lux, V.; Nedomova, M.; Goldman, S. R.; Smith, E. A.; Srb, P.; Hexnerova, R.; Fabry, M.; Madlikova, M.; Horejsi, M.; De Rijck, J.; Debyser, Z.; Adelman, K.; Hodges, H. C.; Veverka, V. A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science 2021, 374, 1113-1121. http://dx.doi.org/10.1126/science.abe2913
• Jílková, A.; Horn, M.; Fanfrlík, J.; Küppers, J.; Pachl, P.; Řezáčová, P.; Lepšík, M.; Fajtová, P.; Rubešová, P.; Chanová, M.; Caffrey, C. R.; Gütschow, M.; Mareš, M. Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity. ACS Inflect Dis. 2021, 7, 189-201. http://dx.doi.org/10.1021/acsinfecdis.0c00644
• Hejdankova, Z.; Vanek, V.; Sedlak, F.; Prochazka, J.; Diederichs, A.; Kereïche, S.; Novotna, B.; Budesinsky, M.; Birkus, G.; Grantz Saskova, K.; Cigler, P. Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery. Adv. Funct. Mater. 2021, 31, 2101391. http://dx.doi.org/10.1002/adfm.202101391
• Dostalik, P.; Krafcikova, P.; Silhan, J.; Kozic, J.; Chalupska, D.; Chalupsky, K.; Boura, E. Structural Analysis of the OC43 Coronavirus 2′-O-RNA Methyltransferase. J Virol. 2021, 95, 10.1128/jvi.00463-21. http://dx.doi.org/10.1128/JVI.00463-21
• Blažková, K.; Beranová, J.; Hradilek, M.; Kostka, L.; Šubr, V.; Etrych, T.; Šácha, P.; Konvalinka, J. The development of a high-affinity conformation-sensitive antibody mimetic using a biocompatible copolymer carrier (iBody). J. Biol. Chem. 2021, 297, 101342. http://dx.doi.org/10.1016/j.jbc.2021.101342

• Smola, M.; Gutten, O.; Dejmek, M.; Kožíšek, M.; Evangelidis, T.; Tehrani, Z. A.; Novotná, B.; Nencka, R.; Birkuš, G.; Rulíšek, L.; Boura, E. Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angew. Chem. Int. Ed. 2021, 60, 10172-10178. http://dx.doi.org/10.1002/anie.202016805
• Mallada, B.; de la Torre, B.; Mendieta-Moreno, J. I.; Nachtigallová, D.; Matěj, A.; Matoušek, M.; Mutombo, P.; Brabec, J.; Veis, L.; Cadart, T.; Kotora, M.; Jelínek, P. On-Surface Strain-Driven Synthesis of Nonalternant Non-Benzenoid Aromatic Compounds Containing Four- to Eight-Membered Rings. J. Am. Chem. Soc. 2021, 143, 14694-14702. http://dx.doi.org/10.1021/jacs.1c06168
• Mallada, B.; Gallardo, A.; Lamanec, M.; de la Torre, B.; Špirko, V.; Hobza, P.; Jelinek, P. Real-space imaging of anisotropic charge of σ-hole by means of Kelvin probe force microscopy. Science 2021, 374, 863-867. http://dx.doi.org/10.1126/science.abk1479
• Mason, P. E.; Schewe, H. C.; Buttersack, T.; Kostal, V.; Vitek, M.; McMullen, R. S.; Ali, H.; Trinter, F.; Lee, C.; Neumark, D. M.; Thürmer, S.; Seidel, R.; Winter, B.; Bradforth, S. E.; Jungwirth, P. Spectroscopic evidence for a gold-coloured metallic water solution. Nature 2021, 595, 673-676. http://dx.doi.org/10.1038/s41586-021-03646-5