IOCB Most Significant Publications 2022

The most significant publications in CHEM, BIO & PHYS clusters are selected annually by an external international panel of reviewers and the IOCB director.

The awarded publications are listed in their respective clusters alphabetically by title.

• Dejmek, M.; Šála, M.; Brazdova, A.; Vanekova, L.; Smola, M.; Klíma, M.; Břehová, P.; Buděšínský, M.; Dračínský, M.; Procházková, E.; Zavřel, M.; Šimák, O.; Páv, O.; Boura, E.; Birkuš, G.; Nencka, R. Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential. Structure 2022, 30, 1146-1156.e11. https://doi.org/10.1016/j.str.2022.05.012
• Kretschmer, J.; David, T.; Dračínský, M.; Socha, O.; Jirak, D.; Vít, M.; Jurok, R.; Kuchař, M.; Císařová, I.; Polasek, M. Paramagnetic encoding of molecules. Nat. Commun. 2022, 13, 3179. https://doi.org/10.1038/s41467-022-30811-9
• Poryvai, A.; Galkin, M.; Shvadchak, V.; Slanina, T. Red-Shifted Water-Soluble BODIPY Photocages for Visualisation and Controllable Cellular Delivery of Signaling Lipids. Angew. Chem. Int. Ed. 2022, 61, e202205855. https://doi.org/10.1002/anie.202205855

• Poláchová, E.; Bach, K.; Heuten, E.; Stanchev, S.; Tichá, A.; Lampe, P.; Majer, P.; Langer, T.; Lemberg, M. K.; Stříšovský, K. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J. Med. Chem. 2023, 66, 251-265. https://doi.org/10.1021/acs.jmedchem.2c01092
• Cutano, V.; Ferreira Mendes, J. M.; Escudeiro-Lopes, S.; Machado, S.; Vinaixa Forner, J.; Gonzales-Morena, J. M.; Prevorovsky, M.; Zemlianski, V.; Feng, Y.; Kralova Viziova, P.; Hartmanova, P.; Malcekova, B.; Jakoube, P.; Iyer, S.; Keckesova, Z. LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug. Life Sci. Alliance 2023, 6, e202201510. https://doi.org/10.26508/lsa.202201510
• Huskova, A.; Dinesh, D. C.; Srb, P.; Boura, E.; Veverka, V.; Silhan, J. Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model. Nucleic Acids Res. 2022, 50, 10436-10448. https://doi.org/10.1093/nar/gkac793
• Kvakova, K.; Ondra, M.; Schimer, J.; Petrik, M.; Novy, Z.; Raabova, H.; Hajduch, M.; Cigler, P. Visualization of Sentinel Lymph Nodes with Mannosylated Fluorescent Nanodiamonds. Adv. Funct. Mater. 2022, 32, 2109960. https://doi.org/10.1002/adfm.202109960

• Nemirovich, T.; Kostal, V.; Copko, J.; Schewe, H. C.; Boháčová, S.; Martinek, T.; Slanina, T.; Jungwirth, P. Bridging Electrochemistry and Photoelectron Spectroscopy in the Context of Birch Reduction: Detachment Energies and Redox Potentials of Electron, Dielectron, and Benzene Radical Anion in Liquid Ammonia. J. Am. Chem. Soc. 2022, 144, 22093-22100. https://doi.org/10.1021/jacs.2c09478
• Kipouros, I.; Stańczak, A.; Ginsbach, J. W.; Andrikopoulos, P. C.; Rulíšek, L.; Solomon, E. I. Elucidation of the tyrosinase/O2/monophenol ternary intermediate that dictates the monooxygenation mechanism in melanin biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2205619119. https://doi.org/10.1073/pnas.2205619119
• Štoček, J. R.; Socha, O.; Císařová, I.; Slanina, T.; Dračínský, M. Importance of Nuclear Quantum Effects for Molecular Cocrystals with Short Hydrogen Bonds. J. Am. Chem. Soc. 2022, 144, 7111-7116. https://doi.org/10.1021/jacs.1c10885
• Lo, R.; Manna, D.; Lamanec, M.; Dračínský, M.; Bouř, P.; Wu, T.; Bastien, G.; Kaleta, J.; Miriyala, V. M.; Špirko, V.; Mašínová, A.; Nachtigallová, D.; Hobza, P. The stability of covalent dative bond significantly increases with increasing solvent polarity. Nat. Commun. 2022, 13, 2107. https://doi.org/10.1038/s41467-022-29806-3