Quality control of integral membrane proteins
The current issue of The EMBO Journal features two back to back papers on quality control of integral membrane proteins from the Kvido Stříšovský Group of IOCB Prague in collaboration with scientists from the University of Marseille and University of Oxford.
The paper Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease from Kvido Stříšovský Group with Jakub Began as the shared first author focuses on the role of rhomboid protease in controlling magnesium homeostasis and transition metal toxicity in Bacillus subtilis.
The companion paper Bacterial rhomboid proteases mediate quality control of orphan membrane proteins from the Tang Group Group of the University of Oxford focuses on the role of rhomboid proteases in clearing the membrane of ‘lost’, orphan membrane proteins that failed to be incorporated into their cognate complexes.
Both papers together establish evolutionarily ancient principles that guide some aspects of the endoplasmic reticulum-associated degradation (ERAD) in eukaryotes, a process whose defects are associated with many disease states.
This extended summary of both papers is nicely covered in the accompanying News and Views article by Knopf and Lemberg in the same issue, and artistically rendered in the cover picture of the issue.
- Began, J.; Cordier, B.; Březinová, J.; Delisle, J.; Hexnerová, R.; Srb, P.; Rampírová, P.; Kožíšek, M.; Baudet, M.; Couté, Y.; Galinier, A.; Veverka, V.; Doan, T.; Strisovsky, K. Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease. The EMBO Journal 2020, 39, e102935.
- Liu, G.; Beaton, S. E.; Grieve, A. G.; Evans, R.; Rogers, M.; Strisovsky, K.; Armstrong, F. A.; Freeman, M.; Exley, R. M.; Tang, C. M. Bacterial rhomboid proteases mediate quality control of orphan membrane proteins. The EMBO Journal 2020, 39, e102922.