Petr Beier Group at IOCB Prague published in Chemistry – A European Journal a novel and practical, metal‐free method for the synthesis of novel β‐enamido‐sulfonates starting from N‐fluoroalkyl‐1,2,3‐triazoles.
The new method has a high functional‐group tolerance and following the synthetic transformation of vinyl triflates in cross‐coupling reactions leads to functionalized enamides.
Furthermore, the researchers were able to prepare 2‐fluoroalkyl oxazoles by a one‐pot procedure from electron‐rich triazoles by the cyclization of vinyl triflate intermediates.
Read the paper:
- Markos, A.; Voltrová, S.; Motornov, V.; Tichý, D.; Klepetářová, B.; Beier, P. Stereoselective Synthesis of (Z)-β-Enamido Triflates and Fluorosulfonates from N-Fluoroalkylated Triazoles. Chemistry – A European Journal 2019, 25, 7640-7644. https://doi.org/10.1002/chem.201901632
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