PhD project
Selection and optimization of modified XNA aptamers
Tutor
Michal Hocek
Group
Michal Hocek Group
Bioorganic and Medicinal Chemistry of Nucleic Acids
Bioorganic and Medicinal Chemistry of Nucleic Acids
Abstract
The topic of the dissertation will be the enzymatic synthesis of hypermodified xeno-nucleic acids and their use in aptamer selection. It will be necessary to develop enzymatic synthesis of modified XNA libraries, selection of binding sequences, reverse transcription into DNA and sequencing. The goal will be the development of stable aptamers binding target molecules (biomarkers, proteins, etc.).
Study program: Organic chemistry
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2026 page and follow the instructions.