PhD project
Synthesis of targeted kinase degraders as experimental therapeutics
Tutor
Michal Hocek
Group
Michal Hocek Group
Bioorganic and Medicinal Chemistry of Nucleic Acids
Bioorganic and Medicinal Chemistry of Nucleic Acids
Abstract
The aim of the thesis will be to synthesize PROTACs for several kinases, which are validated targets in oncology and in CNS disorders. It will be focused on linker optimization, selection of ligase ligands and specificity for target kinase. Our recently developed highly selective small molecule heterocyclic kinase inhibitors will serve as a starting point.
Study program: Organic chemistry
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2026 page and follow the instructions.