PhD project
Enzymatic synthesis of modified oligonucleotides on solid support
Tutor
Michal Hocek
Group
Michal Hocek Group
Bioorganic and Medicinal Chemistry of Nucleic Acids
Bioorganic and Medicinal Chemistry of Nucleic Acids
Abstract
The aim of the thesis will be the development of an efficient enzymatic synthesis of oligonucleotides on solid support. Diverse solid supports and linkers will be tested for attachment of templates and will be used for primer extension with either denaturaion or cleavage of the resulting oligonuclotides by endonucleases. Methods will be then applied for synthesis of oligonucleotides with therapeutic potential.
Study program: Organic chemistry
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
University partners
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2026 page and follow the instructions.