PhD project
Catalytic synthesis of bioactive atropisomers by aromatic substitution
Tutor
Paulo De Souza Paioti
Group
Paulo Paioti Group
Catalytic Synthesis of Bioactive Molecules
Catalytic Synthesis of Bioactive Molecules
Abstract
Our group recently developed nucleophilic aromatic substitutions for synthesis of drug-like atropisomers, chiral conformational isomers originating from restricted single bond rotation. In this context, we discovered a fluoride-catalyzed strategy that is remarkably efficient. In this PhD thesis, we will explore this reactivity for synthesis of atropisomers and other bioactive compounds. The primary goal is to advance the field of catalytic organic synthesis. In collaboration, we will evaluate biological activity of the unique molecules synthesized during the project.
Study program: Organic chemistry
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2026 page and follow the instructions.