Construction of N-trifluoromethylated compounds as new building blocks in life science from azidofluoroalkanes
Abstract
Organic azides play a crucial role in chemistry and biochemistry due to their unique reactivity and versatility. Organic fluorinated azides are derivatives of azidoalkanes developed by us recently.1-3 In this project we will study their transformation to N-trifluoromethylated amides and properties and derivatization of those amides, in order to discover new reactivity and prepare new building blocks for life science.
Key references:
- Z. E. Blastik, et al. Angew. Chem., Int. Ed. 2017, 56, 346.
- O. Bakhanovich, et al. Chem. Eur. J. 2020, 26, 77.
- A. Kubíčková, et al. Org. Chem. Front. 2023, 10, 3201.
Study program: Organic chemistry
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
University partners
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2026 page and follow the instructions.