Profile

Positions


2022 Associate Professor in Genetics, Molecular Biology and Virology, Charles University, Faculty of Science, Prague, Czech Republic
2018 Assistant Professor, Charles University, Faculty of Science, Prague, Czech Republic
since 2018Head of the Laboratory of Structural Biology of Transcription Regulation, Charles University, Faculty of Science, Department of Cell Biology, Prague, Czech Republic
since 2012Senior PI, IOCB Prague, Structural Biology, Program leader for Biomolecular NMR
2009-2012Industrial research fellow, University of Leicester, United Kingdom
2003-2009Postdoctoral fellow, University of Leicester, United Kingdom


Selected papers

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif
Nature Communications 6: 7968 (2015)
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers
Nature Structural & Molecular Biology 25 (1): 61-72 (2018)
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation
Proceedings of the National Academy of Sciences of the United States of America 115 (30): E7053-E7062 (2018)

Latest publications

Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers
Nucleic Acids Research 2024: Early View
The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function
Cells 13 (3): 227 (2024)
Development and characterization of a chronic hepatitis B murine model with a mutation in the START codon of an HBV polymerase
Physiological Research 72 (1): 37–47 (2023)