Profile

Positions


2022 Associate Professor in Genetics, Molecular Biology and Virology, Charles University, Faculty of Science, Prague, Czech Republic
2018 Assistant Professor, Charles University, Faculty of Science, Prague, Czech Republic
since 2018Head of the Laboratory of Structural Biology of Transcription Regulation, Charles University, Faculty of Science, Department of Cell Biology, Prague, Czech Republic
since 2012Senior PI, IOCB Prague, Structural Biology, Program leader for Biomolecular NMR
2009-2012Industrial research fellow, University of Leicester, United Kingdom
2003-2009Postdoctoral fellow, University of Leicester, United Kingdom


Selected papers

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif
Nature Communications 6: 7968 (2015)
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers
Nature Structural & Molecular Biology 25 (1): 61-72 (2018)
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation
Proceedings of the National Academy of Sciences of the United States of America 115 (30): E7053-E7062 (2018)

Latest publications

The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder
Biochemical Society Transactions 51 (1): 125–135 (2023)
Multiparametric Flow Cytometry-Based Immunophenotyping of Mouse Liver Immune Cells
Methods and Protocols 5 (5): 70 (2022)
Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model
Nucleic Acids Research 50 (18): 10436–10448 (2022)
FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA
Protein Science 31 (5): e4287 (2022)