Jan Skácel, Martin Dračínský and Zlatko Janeba from IOCB Prague have developed a new synthetic strategy, allowing the preparation of previously rarely synthesized asymmetrically tetrasubstituted thiophenes
Direct metalation employing the Knochel—Hauser bases and subsequent reaction with corresponding electrophiles allow for a straightforward synthesis of this class of substances with excellent regioselectivity control and good yields.
Read the paper:
- Skácel, J.; Dračínský, M.; Janeba, Z. Synthesis of Tetrasubstituted Thiophenes via Direct Metalation. The Journal of Organic Chemistry 2020, 85, 788-797. https://doi.org/10.1021/acs.joc.9b02803
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