• Home
  • Press room
  • News
  • The role of α-synuclein interactions with lipid membrane in Parkinson’s disease
Short news

The role of α-synuclein interactions with lipid membrane in Parkinson’s disease

30 April 2021
The role of α-synuclein interactions with lipid membrane in Parkinson’s disease

Parkinson’s disease is a progressive disorder of the central nervous system affecting movements. α-Synuclein is a neuronal protein consisting of 140 amino acids, which is closely connected with Parkinson’s disease. During Parkinson’s disease, α-synuclein aggregates, forming amyloid fibrils that accumulate in the midbrain. The interactions of α-synuclein with lipid membranes regulate the fibrillization process.

A team of scientists led by Volodymyr Shvadchak from IOCB Prague applied the environment-sensitive fluorescent dyes to study the influence of model lipid membranes on the kinetics of α-synuclein fibrils formation. The analysis showed that the formation of fibrils from α-synuclein monomers is strongly delayed by small amounts of lipids. Besides, the α-synuclein monomers bound to the membrane are not involved in the fibrils elongation process. The study was published in ACS Chemical Neuroscience.

Read the paper:

Share this article
Read next...
See all news arrow