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Publications
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Nonconsensus flanking sequence of hundreds of base pairs around in vivo binding sites: statistical beacons for transcription factor scanning
Nucleic Acids Research 54 (14): gkag514 (2026)
Transcription factor (TF) binding is typically described in terms of short sequence motifs and their immediate flanking regions. However, increasing evidence suggests that broader genomic context may influence TF–DNA interactions. By a thorough analysis of the DNA sequence in the broad context ( 5000 bp) of in vivo binding sites (as identified in a ChIP-seq or a Cut&Tag experiment), we show that the average GC content is in most cases statistically significantly increased around the binding site in a patch spanning 1000–1500 bp. This increase was observed consistently in experiment targeting the same TF in different cell lines. The surrounding of binding sites of certain TFs like MYC display a directional alteration of dinucleotide frequencies. Using sequence-derived structural descriptors, we hypothesize that DNA shape reflects (and may partly explain) patterns in sequence composition. In addition, we observe differences in sequence affinity to various potential cooperating TFs…
Making Prodrugs Stick Around: Engineering Protease-Activated Tumor Retention
ACS Central Science 12 (7): 888–890 (2026)
Axial Symmetry Directs Ligand Orientation in Galectin-3
Journal of Medicinal Chemistry 2026: Early View
EneoC, a queen-specific terpene synthase, produces the queen pheromone in epidermal secretory cells of Embiratermes neotenicus queen
Insect Biochemistry and Molecular Biology 194: 104631 (2026)