RNDr. Jan Blahut, Ph.D.
+420 607 619 939
+420 220 183 120
Vybrané publikace
Sensitivity-Enhanced Multidimensional Solid-State NMR Spectroscopy by Optimal-Control-Based Transverse Mixing Sequences
Journal of the American Chemical Society 144 (38): 17336–17340 (2022)
Recently, proton-detected magic-angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) spectroscopy has become an attractive tool to study the structure and dynamics of insoluble proteins at atomic resolution. The sensitivity of the employed multidimensional experiments can be systematically improved when both transversal components of the magnetization are transferred simultaneously after an evolution period. The method of preservation of equivalent pathways has been explored in solution-state NMR; however, it does not find widespread application due to relaxation issues connected with increased molecular size. We present here for the first time heteronuclear transverse mixing sequences for correlation experiments at moderate and fast MAS frequencies. Optimal control allows to boost the signal-to-noise ratio (SNR) beyond the expected factor of for each indirect dimension. In addition to the carbon-detected sensitivity-enhanced 2D NCA experiment, we present a novel proton…
The hydrogen bond continuum in solid isonicotinic acid
Journal of Magnetic Resonance 345: 107334 (2022)
Nejnovější publikace
13C Solid-State NMR Chemical Shift Reproducibility across Spectrometers
Solid State Nuclear Magnetic Resonance 145: 102123 (2026)
Disentangling molecular and macroscopic motion in a salient solvate
Materials Chemistry Frontiers 10 (18): 3305–3313 (2026)
Characterization of Fludarabine Phosphate Crystalline Forms
Crystal Growth and Design 26 (15): 6136–6141 (2026)
New Insights into the Structure and Thermodynamic Stability of Polymorphs I and II of the Nicotinamide:Adipic Acid Co-Crystal: A BEST-CSP Study
Crystal Growth and Design 26 (14): 5618–5628 (2026)