Vybrané publikace

Pyrrolo[2,3‐<i>d</i>]pyrimidine (7‐deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides
Pyrrolo[2,3‐d]pyrimidine (7‐deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides
Medicinal Research Reviews 37 (6): 1429-1460 (2017)
7‐Deazapurine (pyrrolo[2,3‐d]pyrimidine) nucleosides are important analogues of biogenic purine nucleosides with diverse biological activities. Replacement of the N7 atom with a carbon atom makes the five‐membered ring more electron rich and brings a possibility of attaching additional substituents at the C7 position. This often leads to derivatives with increased base‐pairing in DNA or RNA or better binding to enzymes. Several types of 7‐deazapurine nucleosides with potent cytostatic or cytotoxic effects have been identified. The most promising are 7‐hetaryl‐7‐deazaadenosines, which are activated in cancer cells by phosphorylation and get incorporated both to RNA (causing inhibition of proteosynthesis) and to DNA (causing DNA damage). Mechanism of action of other types of cytostatic nucleosides, 6‐hetaryl‐7‐deazapurine and thieno‐fused deazapurine ribonucleosides, is not yet known. Many 7‐deazaadenosine derivatives are potent inhibitors of adenosine kinases. Many types of…

Nejnovější publikace

Synthesis of cytochalasan analogues with aryl substituents at position 10
Organic and Biomolecular Chemistry 2024: Early View
Synthesis and migrastatic activity of cytochalasin analogues lacking a macrocyclic moiety
RSC Medicinal Chemistry 15 (1): 322-343 (2024)
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
Journal of Medicinal Chemistry 65 (20): 14082–14103 (2022)
Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides
ACS Infectious Diseases 7 (4): 917–926 (2021)