Paul Knochel

13. března 2008
Prof. Paul Knochel (Ludwig-Maximilians-Universität, Munich, Německo)
Functionalized Mg and Zn-Organometallics for Organic Synthesis


In the first part of the lecture, the preparation of highly functionalized organozinc compounds will be emphasized using zinc powder in the presence of LiCl.1 This method allows the preparation of a range of heteroarylzinc species bearing a ketone or an aldehyde. In a second part, the preparation of polyfunctional magnesiated heterocycles using either a X/Mg- exchange triggered by i-PrMgCl-LiCl or by a direct deprotonation using new soluble Mg-bases such as TMPMgCl-LiCl or (TMP)2Mg-2LiCl.2 Applications of these polyfunctional organometallics for the synthesis of bioactive molecules will be shown.3 Finally, the synthesis of aminated heterocycles using an oxidative amination procedure with chloranil will be described.4


  1. Krasovskiy, A.; Gavryushin, A.; Malakhov, V.; Knochel, P. Angew. Chem. Int. Ed. 2006, 45, 6040. 
  2. Boudet, N.; Knochel, P. Org. Lett. 2006, 8, 3737.  
  3. Krasovskiy, A.; Krasovskaya, V.; Knochel, P. Angew. Chem. Int. Ed. 2006, 45, 2958.  
  4. del Amo, V.; Dubbaka, S.; Krasovskiy, A.; Knochel, P. Angew. Chem. Int. Ed. 2006, 45, 7838.
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