15. dubna 2019
Prof. Venki Ramakrishnan (MRC Laboratory of Molecular Biology, Cambridge, Spojené království)
Termination of Translation in Bacteria and Eukaryotes
Datum a čas
15. dubna 2019, 10:00
Přednáškový sál ÚOCHB (budova A, 2. NP, A2.01)
Termination of translation in all domains of life is triggered by the entry of a stop codon in the A site of the ribosome. These three codons are recognized by a protein release factor. However, release factors in bacteria and eukaryotes appear to have no structural or sequence similarity. In this talk, I will describe structural work that sheds the basis of release factor function in the two domains of life and show that despite their dissimilarity, they share certain common features.