Váš webový prohlížeč je zastaralý. Aktualizujte svůj prohlížeč pro větší bezpečnost, rychlost a nejlepší zkušenosti na tomto webu

Michael J. Krische

20. dubna 2016
ÚOCHB
Přednášející
Prof. Michael J. Krische (Department of Chemistry and Biochemistry, University of Texas at Austin, Texas, USA)
Téma
Formation of C-C Bonds via Catalytic Hydrogenation and Transfer Hydrogenation

Abstrakt

Reductive C-C bond formation via catalytic hydrogenation and related H2-auto-transfer processes for the direct conversion of lower alcohols to higher alcohols are described. These transformations merge redox and C-C bond construction events, bypassing stoichiometric use of premetalated reagents. Due to a kinetic preference for primary alcohol dehydrogenation, site-selective modification of glycols and higher polyols occurs in the absence of protecting groups. To benchmark the utility of these methods, total syntheses of several iconic type I polyketide natural products were undertaken, in each case, availing routes significantly more concise than previously achieved.
Sdílet článek