Zvaná přednáška – Michael J. Krische

20. dubna 2016
Zvaná přednáška – Michael J. Krische

Prof. Michael J. Krische (Department of Chemistry and Biochemistry, University of Texas at Austin, Texas, USA)


Formation of C-C Bonds via Catalytic Hydrogenation and Transfer Hydrogenation


Reductive C-C bond formation via catalytic hydrogenation and related H2-auto-transfer processes for the direct conversion of lower alcohols to higher alcohols are described. These transformations merge redox and C-C bond construction events, bypassing stoichiometric use of premetalated reagents. Due to a kinetic preference for primary alcohol dehydrogenation, site-selective modification of glycols and higher polyols occurs in the absence of protecting groups. To benchmark the utility of these methods, total syntheses of several iconic type I polyketide natural products were undertaken, in each case, availing routes significantly more concise than previously achieved.

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