Zvaná přednáška – Bernd Giese

5. listopadu 2012
Zvaná přednáška – Bernd Giese

Prof. Bernd Giese (University of Fribourg, Švýcarsko)


Electron Transfer through Peptides: Consequences for Enzymatic Reactions


Long-range electron transfer (ET) through proteins is a fundamental reaction in living organisms, playing a role in energy-conversion processes like photosynthesis and respiration as well as in enzymatic reactions. The mechanism of these ET processes over long distances is a matter of controversy. We have developed a new assay that allows the measurement of ET rates and ET efficiencies.


The results are:
  1. Heteroaromatic and S-containing amino acids act as relay amino acids that induce ET by a hopping mechanism. 
  2. Charges dramatically influence ET rates. 
  3. The direction of the ET process and the sec. structure of the peptide plays an important role. 
  4. Rates increase with increase of the driving force and decrease with increasing donor/acceptor distance.
The consequences for enzymatic reactions and nanoelectronic applications will be discussed.

Latest publication giving further literature: Gao, J.; Müller, P.; Wang, M.; Eckhardt, S.; Lauz, M.; Fromm, K. M.; Giese, B. Angew. Chem. 2011, 50, 1926. 

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