Nejvýznamnější publikace 2025

Mezinárodní panel expertů a ředitel ÚOCHB každoročně vybírají nejvýznamnější publikace ÚOCHB v klustrech CHEM, BIO a PHYS.

Oceněné publikace jsou rozděleny podle klastrů a uvedeny v abecedním pořadí podle názvu.

• Brungs, C.; Schmid, R.; Heuckeroth, S.; Mazumdar, A.; Drexler, M.; Šácha, P.; Dorrestein, P.; Petras, D.; Nothias, L.; Veverka, V.; Nencka, R.; Kameník, Z.; Pluskal, T.* MSnLib: efficient generation of open multi-stage fragmentation mass spectral libraries. Nature Methods 2025, 22, 2028-2031. https://doi.org/10.1038/s41592-025-02813-0
• Jones, K.G.; David, T.; Loula, M.; Matějková, S.; Blahut, J.; Filimoněnko, A.; Litecká, M.; Rohlíček, J.; Böserle, J.; Polášek, M.* Macrocyclic Chelators for Aqueous Lanthanide Separations via Precipitation: Toward Sustainable Recycling of Rare-Earths from NdFeB Magnets. Journal of the American Chemical Society 2025, 147, 22666-22676. https://doi.org/10.1021/jacs.5c04150
• Šimek, M.; Dey, P.; Blahout, V.; Mondal, K.; Ernenwein, J.; Dračínský, M.; Bím, D.*; Paioti, P. H. S.* Nucleophilic aromatic substitutions enable diversity-oriented synthesis of heterocyclic atropisomers via non-atropisomeric intermediates. Nature Communications 2025, 16, 4856. https://doi.org/10.1038/s41467-025-60101-z

Director's Award

• Rahm, M.; Keppel, P.; Šlachtová, V.; Dzijak, R.; Dračínský, M.; Bellová, S.; Reyes Gutierrez, P.E.; Štěpánová, S.; Raffler, J.; Tloušťová, E.; Mertlíková-Kaiserová, H.; Mikula, H.; Vrábel, M. Sulfonated Hydroxyaryl-Tetrazines with Increased pKa for Accelerated Bioorthogonal Click-to-Release Reactions in Cells. Angewandte Chemie - International Edition 2025, 64, e202411713. https://doi.org/10.1002/anie.202411713

• Pabba, M.; Kuba, M.; Kraus, T.; Celikay, K.; Meyer, J.; Pradhan, S.; Maiser, A.; Harz, H.; Leonhardt, H.; Rohr, K.; Hocek, M.*; Cardoso, M.* Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation. Advanced Science 2025, 12, e05955. https://doi.org/10.1002/advs.202505955
• Valenstein, M.; Wranik, M.; Lalgudi, P.; Linde-Garelli, K.; Choi, Y.; Chivukula, R.; Sabatini, D.M*.; Rogala, K.* Structural basis for the dynamic regulation of mTORC1 by amino acids. Nature 2025, 646, 493-500. https://doi.org/10.1038/s41586-025-09428-7
• Warner, J.; Lux, V.; Veverka, V.*; Winston, F.* The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain. Molecular Cell 2025, 85, 3407-3424. https://doi.org/10.1016/j.molcel.2025.08.020
• Král, M.; Das, A.; Kotačka, T.; Blahošová, A.; Liščáková, V.; Hodek, J.; Konvalinka, J.; Demo, G.*; Kožíšek, M.* Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights. ACS Infectious Diseases 2025, 11,3364-3376. https://doi.org/10.1021/acsinfecdis.5c00832

• Bushuiev, R.; Bushuiev, A.; Samusevich, R.; Brungs, C.; Šivic, J.; Pluskal, T.* Self-supervised learning of molecular representations from millions of tandem mass spectra using DreaMS. Nature Biotechnology 2026, 44, 630–640. https://doi.org/10.1038/s41587-025-02663-3
• Lo, R.; Manna, D.; Vacek ml., J.; Bouř, P.; Wu, T.; Osifová, Z.; Socha, O.; Dračínský, M.; Hobza, P.* Striking Impact of Solvent Polarity on the Strength of Hydrogen-Bonded Complexes: A Nexus Between Theory and Experiment. Angewandte Chemie - International Edition 2025, 64, e202422594. https://doi.org/10.1002/anie.202422594
• Vitek, M.; Rončević, I.; Maršálek, O.; Schewe, H.C.; Jungwirth, P.* Rapid flipping between electrolyte and metallic states in ammonia solutions of alkali metals. Nature Communications 2025, 16, 4302. https://doi.org/10.1038/s41467-025-59071-z